Histological validation of dynamic-equilibrium cardiovascular magnetic resonance for the measurement of myocardial extracellular volume
نویسندگان
چکیده
Background Extracellular matrix expansion is fundamental to left ventricular (LV) remodeling, and is a therapeutic target. CMR techniques are increasingly used to evaluate myocardial extracellular volume (ECV), however the most widely applied methods are without histological validation. The aim of this study was to provide whole-heart, histological validation of; 1. Dynamic-equilibrium CMR (DynEq-CMR), where ECV is quantified using hematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus; and 2. Isolated measurement of myocardial T1 at a fixed time-point following gadolinium bolus, used as an ECV surrogate.
منابع مشابه
Letter by Iles and Taylor regarding article, "Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume".
BACKGROUND Extracellular matrix expansion is a key element of ventricular remodeling and a potential therapeutic target. Cardiovascular magnetic resonance (CMR) T1-mapping techniques are increasingly used to evaluate myocardial extracellular volume (ECV); however, the most widely applied methods are without histological validation. Our aim was to perform comprehensive validation of (1) dynamic-...
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عنوان ژورنال:
دوره 15 شماره
صفحات -
تاریخ انتشار 2013